House entered a seventh season on September 20, 2010.^[2] House and Cuddy attempt to make a real relationship work and face the question as to whether their new relationship will affect their ability to diagnose patients.^[6] The new season features a new opening title sequence.^[7] This is the first change in the opening sequence since the show began; Jennifer Morrison's name has been removed from the credits, while Peter Jacobson's and Olivia Wilde's have been added to it, with new background images also inserted into traditional title sequence.

Prior to the start of the remainder of the season in 2011, it was announced that a multi-episode arc that would feature House on the road was scrapped, forcing David Shore to return to the show to rework the rest of the season. Furthermore, Fox ordered one more episode for the season, bringing the total number of episodes to 23.^[1] The last episode of the season aired on May 23, 2011.^[8]